Interações medicamentosas
Cyclosporin + Revefenacin
Gravidade: Grave
Cyclosporin and Revefenacin: major interaction.
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Resumo
Cyclosporine inhibits hepatic uptake transporters OATP1B1 and OATP1B3, which can raise systemic exposure to the active metabolite of inhaled revefenacin. Higher exposure could increase anticholinergic adverse effects such as dry mouth, urinary retention and tachycardia.
O que esta interação significa em palavras simples
Cyclosporin and Revefenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Revefenacin belongs to Respiratory.
Por que acontece
Cyclosporine inhibits OATP1B1/OATP1B3-mediated uptake, reducing hepatic clearance of revefenacin's active metabolite.
O que fazer
Coadministration is not recommended per labeling; choose an alternative long-acting bronchodilator if cyclosporine is needed. If unavoidable, monitor for anticholinergic effects.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicada
- Aliskiren + Cyclosporin Contraindicada
- Bcg vaccine live + Cyclosporin Contraindicada
- Bosentan + Cyclosporin Contraindicada
- Cidofovir + Cyclosporin Contraindicada
- Cyclosporin + Dengue vaccine Contraindicada
Outras interações de Revefenacin
- Indacaterol-glycopyrronium + Revefenacin Grave
- Revefenacin + Rifampicin Grave
- Revefenacin + Tiotropium Grave
- Atropine + Revefenacin Moderada
- Benztropine + Revefenacin Moderada
- Darifenacin + Revefenacin Moderada
Perguntas frequentes
Can I take Cyclosporin with Revefenacin?
MediHelp rates the interaction as major. Cyclosporin and Revefenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine inhibits hepatic uptake transporters OATP1B1 and OATP1B3, which can raise systemic exposure to the active metabolite of inhaled revefenacin. Higher exposure could increase anticholinergic adverse effects such as dry mouth, urinary retention and tachycardia.
How serious is the interaction between Cyclosporin and Revefenacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Coadministration is not recommended per labeling; choose an alternative long-acting bronchodilator if cyclosporine is needed. If unavoidable, monitor for anticholinergic effects.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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