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Interações medicamentosas

Dabigatran etexilate + Defibrotide

Gravidade: Contraindicada

Dabigatran etexilate and Defibrotide: contraindicated interaction.

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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

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Resumo

Defibrotide has profibrinolytic activity and may enhance the bleeding risk of anticoagulants. Together with dabigatran this can cause serious hemorrhage.

O que esta interação significa em palavras simples

Dabigatran etexilate and Defibrotide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Dabigatran etexilate belongs to Cardiovascular; Defibrotide belongs to Cardiovascular.

Nível de evidência: Moderate

Por que acontece

Additive pharmacodynamic effects on hemostasis from thrombin inhibition and enhanced fibrinolysis.

O que fazer

Avoid concurrent use; hold dabigatran during defibrotide therapy as directed by the specialist team, considering renal function for washout timing.

O que perguntar ao farmacêutico

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

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Perguntas frequentes

Can I take Dabigatran etexilate with Defibrotide?

MediHelp rates the interaction as contraindicated. Dabigatran etexilate and Defibrotide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Defibrotide has profibrinolytic activity and may enhance the bleeding risk of anticoagulants. Together with dabigatran this can cause serious hemorrhage.

How serious is the interaction between Dabigatran etexilate and Defibrotide?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; hold dabigatran during defibrotide therapy as directed by the specialist team, considering renal function for washout timing.

What other medicines interact with Dabigatran etexilate?

MediHelp also lists interactions of Dabigatran etexilate with, for example, Ketorolac, Mifepristone, Abciximab. The full list is on the Dabigatran etexilate page.

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