Interações medicamentosas
Defibrotide + Enoxaparin
Gravidade: Contraindicada
Defibrotide and Enoxaparin: contraindicated interaction.
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Resumo
Defibrotide has profibrinolytic and antithrombotic activity, so combining it with enoxaparin at treatment doses raises hemorrhage risk. Labeling contraindicates concurrent systemic anticoagulant therapy.
O que esta interação significa em palavras simples
Defibrotide and Enoxaparin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Defibrotide belongs to Cardiovascular; Enoxaparin belongs to Cardiovascular.
Por que acontece
Additive pharmacodynamic effects on hemostasis.
O que fazer
Hold therapeutic enoxaparin during defibrotide treatment and reassess the need for anticoagulation.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Enoxaparin
- Enoxaparin + Ketorolac Contraindicada
- Enoxaparin + Mifepristone Contraindicada
- Abciximab + Enoxaparin Grave
- Aceclofenac + Enoxaparin Grave
- Acetylsalicylic acid + Enoxaparin Grave
- Alteplase + Enoxaparin Grave
Outras interações de Defibrotide
- Alteplase + Defibrotide Contraindicada
- Apixaban + Defibrotide Contraindicada
- Argatroban + Defibrotide Contraindicada
- Dabigatran etexilate + Defibrotide Contraindicada
- Dalteparin + Defibrotide Contraindicada
- Defibrotide + Edoxaban Contraindicada
Perguntas frequentes
Can I take Defibrotide with Enoxaparin?
MediHelp rates the interaction as contraindicated. Defibrotide and Enoxaparin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Defibrotide has profibrinolytic and antithrombotic activity, so combining it with enoxaparin at treatment doses raises hemorrhage risk. Labeling contraindicates concurrent systemic anticoagulant therapy.
How serious is the interaction between Defibrotide and Enoxaparin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold therapeutic enoxaparin during defibrotide treatment and reassess the need for anticoagulation.
What other medicines interact with Enoxaparin?
MediHelp also lists interactions of Enoxaparin with, for example, Ketorolac, Mifepristone, Abciximab. The full list is on the Enoxaparin page.
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