Interações medicamentosas
Danazol + Flutamide
Gravidade: Moderada
Danazol and Flutamide: moderate interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Danazol is a CYP3A4 inhibitor and may increase flutamide exposure. In addition, danazol is an androgen and would oppose the intended antiandrogen effect of flutamide.
O que esta interação significa em palavras simples
Danazol and Flutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Por que acontece
Danazol inhibits CYP3A4 and has pharmacodynamic androgenic activity opposing flutamide.
O que fazer
Avoid the combination where possible because their effects are opposed. If used, monitor liver function tests.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Flutamide
Perguntas frequentes
Can I take Danazol with Flutamide?
MediHelp rates the interaction as moderate. Danazol and Flutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a CYP3A4 inhibitor and may increase flutamide exposure. In addition, danazol is an androgen and would oppose the intended antiandrogen effect of flutamide.
How serious is the interaction between Danazol and Flutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible because their effects are opposed. If used, monitor liver function tests.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Levoketoconazole, Pexidartinib. The full list is on the Flutamide page.
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