Interações medicamentosas
Defibrotide + Fondaparinux
Gravidade: Contraindicada
Defibrotide and Fondaparinux: contraindicated interaction.
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Resumo
Defibrotide enhances fibrinolysis and has antithrombotic effects, so with fondaparinux the risk of serious bleeding is increased. Defibrotide labeling contraindicates concurrent systemic anticoagulant or fibrinolytic therapy.
O que esta interação significa em palavras simples
Defibrotide and Fondaparinux are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Defibrotide belongs to Cardiovascular; Fondaparinux belongs to Cardiovascular.
Por que acontece
Additive pharmacodynamic effects on hemostasis through factor Xa inhibition plus enhanced fibrinolysis.
O que fazer
Do not co-administer; hold fondaparinux during defibrotide treatment or use an alternative plan. Line maintenance or reopening of central lines is the usual exception.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Fondaparinux
- Fondaparinux + Ketorolac Contraindicada
- Abciximab + Fondaparinux Grave
- Aceclofenac + Fondaparinux Grave
- Acetylsalicylic acid + Fondaparinux Grave
- Alteplase + Fondaparinux Grave
- Apixaban + Fondaparinux Grave
Outras interações de Defibrotide
- Alteplase + Defibrotide Contraindicada
- Apixaban + Defibrotide Contraindicada
- Argatroban + Defibrotide Contraindicada
- Dabigatran etexilate + Defibrotide Contraindicada
- Dalteparin + Defibrotide Contraindicada
- Defibrotide + Edoxaban Contraindicada
Perguntas frequentes
Can I take Defibrotide with Fondaparinux?
MediHelp rates the interaction as contraindicated. Defibrotide and Fondaparinux are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Defibrotide enhances fibrinolysis and has antithrombotic effects, so with fondaparinux the risk of serious bleeding is increased. Defibrotide labeling contraindicates concurrent systemic anticoagulant or fibrinolytic therapy.
How serious is the interaction between Defibrotide and Fondaparinux?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; hold fondaparinux during defibrotide treatment or use an alternative plan. Line maintenance or reopening of central lines is the usual exception.
What other medicines interact with Fondaparinux?
MediHelp also lists interactions of Fondaparinux with, for example, Ketorolac, Abciximab, Aceclofenac. The full list is on the Fondaparinux page.
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