Interações medicamentosas
Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df
Gravidade: Contraindicada
Didanosine and Elvitegravir / cobicistat / emtricitabine / tenofovir df: contraindicated interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
This fixed-dose product is a complete HIV regimen and is not intended for use with other antiretrovirals. Tenofovir also raises didanosine exposure, increasing risks of pancreatitis, neuropathy and lactic acidosis, and can blunt CD4 recovery.
O que esta interação significa em palavras simples
Didanosine and Elvitegravir / cobicistat / emtricitabine / tenofovir df are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Tenofovir increases didanosine concentrations, with additive mitochondrial toxicity and duplicate nucleoside therapy.
O que fazer
Do not co-administer; stop didanosine if the single-tablet regimen is used and select an alternative regimen if didanosine is essential.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Didanosine
- Didanosine + Hydroxycarbamide Contraindicada
- Didanosine + Hydroxyurea Contraindicada
- Didanosine + Ribavirin Contraindicada
- Didanosine + Stavudine Contraindicada
- Allopurinol + Didanosine Grave
- Atidarsagene autotemcel + Didanosine Grave
Perguntas frequentes
Can I take Didanosine with Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates the interaction as contraindicated. Didanosine and Elvitegravir / cobicistat / emtricitabine / tenofovir df are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. This fixed-dose product is a complete HIV regimen and is not intended for use with other antiretrovirals. Tenofovir also raises didanosine exposure, increasing risks of pancreatitis, neuropathy and lactic acidosis, and can blunt CD4 recovery.
How serious is the interaction between Didanosine and Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; stop didanosine if the single-tablet regimen is used and select an alternative regimen if didanosine is essential.
What other medicines interact with Didanosine?
MediHelp also lists interactions of Didanosine with, for example, Hydroxycarbamide, Hydroxyurea, Ribavirin. The full list is on the Didanosine page.
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