Interações medicamentosas
Didanosine + Hydroxycarbamide
Gravidade: Contraindicada
Didanosine and Hydroxycarbamide: contraindicated interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Combining hydroxycarbamide with didanosine has been associated with pancreatitis, hepatotoxicity and peripheral neuropathy, some fatal. The combination also appears to worsen immunologic outcomes in HIV.
O que esta interação significa em palavras simples
Didanosine and Hydroxycarbamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Didanosine belongs to Anti Virals; Hydroxycarbamide belongs to Oncology.
Por que acontece
Overlapping toxicities, with hydroxycarbamide possibly increasing didanosine active metabolite activity and mitochondrial toxicity.
O que fazer
Avoid the combination and use alternative antiretrovirals without these toxicities. Monitor lipase, liver enzymes and neurologic symptoms if prior exposure occurred.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Didanosine e Hydroxycarbamide, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 7 dias na web. Sem cartão.
Outras interações de Hydroxycarbamide
- Hydroxycarbamide + Stavudine Contraindicada
Outras interações de Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicada
- Didanosine + Hydroxyurea Contraindicada
- Didanosine + Ribavirin Contraindicada
- Didanosine + Stavudine Contraindicada
- Allopurinol + Didanosine Grave
- Atidarsagene autotemcel + Didanosine Grave
Perguntas frequentes
Can I take Didanosine with Hydroxycarbamide?
MediHelp rates the interaction as contraindicated. Didanosine and Hydroxycarbamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining hydroxycarbamide with didanosine has been associated with pancreatitis, hepatotoxicity and peripheral neuropathy, some fatal. The combination also appears to worsen immunologic outcomes in HIV.
How serious is the interaction between Didanosine and Hydroxycarbamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use alternative antiretrovirals without these toxicities. Monitor lipase, liver enzymes and neurologic symptoms if prior exposure occurred.
What other medicines interact with Hydroxycarbamide?
MediHelp also lists interactions of Hydroxycarbamide with, for example, Stavudine. The full list is on the Hydroxycarbamide page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
