Interações medicamentosas
Didanosine + Stavudine
Gravidade: Contraindicada
Didanosine and Stavudine: contraindicated interaction.
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Resumo
Combining these two nucleoside analogues markedly raises the risk of pancreatitis, peripheral neuropathy and lactic acidosis with hepatic steatosis. Fatal cases have been reported, particularly in pregnant women.
O que esta interação significa em palavras simples
Didanosine and Stavudine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Didanosine belongs to Anti Virals; Stavudine belongs to Anti Virals.
Por que acontece
Additive mitochondrial toxicity from inhibition of mitochondrial DNA polymerase gamma.
O que fazer
Avoid the combination and use a safer nucleoside backbone. If already on it, switch promptly and monitor for symptoms of pancreatitis, neuropathy and lactic acidosis.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Stavudine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Stavudine Contraindicada
- Hydroxycarbamide + Stavudine Contraindicada
- Stavudine + Zidovudine Contraindicada
- Atidarsagene autotemcel + Stavudine Grave
- Betibeglogene autotemcel + Stavudine Grave
- Elivaldogene autotemcel + Stavudine Grave
Outras interações de Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicada
- Didanosine + Hydroxycarbamide Contraindicada
- Didanosine + Hydroxyurea Contraindicada
- Didanosine + Ribavirin Contraindicada
- Allopurinol + Didanosine Grave
- Atidarsagene autotemcel + Didanosine Grave
Perguntas frequentes
Can I take Didanosine with Stavudine?
MediHelp rates the interaction as contraindicated. Didanosine and Stavudine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining these two nucleoside analogues markedly raises the risk of pancreatitis, peripheral neuropathy and lactic acidosis with hepatic steatosis. Fatal cases have been reported, particularly in pregnant women.
How serious is the interaction between Didanosine and Stavudine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a safer nucleoside backbone. If already on it, switch promptly and monitor for symptoms of pancreatitis, neuropathy and lactic acidosis.
What other medicines interact with Stavudine?
MediHelp also lists interactions of Stavudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Hydroxycarbamide, Zidovudine. The full list is on the Stavudine page.
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