Interações medicamentosas
Didanosine + Hydroxyurea
Gravidade: Contraindicada
Didanosine and Hydroxyurea: contraindicated interaction.
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Resumo
Hydroxyurea combined with didanosine has caused pancreatitis, hepatotoxicity including fatal hepatic failure, and peripheral neuropathy in HIV patients. The overlapping toxicities make the combination dangerous.
O que esta interação significa em palavras simples
Didanosine and Hydroxyurea are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Didanosine belongs to Anti Virals; Hydroxyurea belongs to Miscellaneous.
Por que acontece
Additive pancreatic, hepatic and neurotoxicity; the exact mechanism is not fully established.
O que fazer
Do not combine; choose a different antiretroviral. If exposure has occurred, monitor for pancreatitis, liver injury and neuropathy and stop the agents if signs appear.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicada
- Didanosine + Hydroxycarbamide Contraindicada
- Didanosine + Ribavirin Contraindicada
- Didanosine + Stavudine Contraindicada
- Allopurinol + Didanosine Grave
- Atidarsagene autotemcel + Didanosine Grave
Outras interações de Hydroxyurea
Perguntas frequentes
Can I take Didanosine with Hydroxyurea?
MediHelp rates the interaction as contraindicated. Didanosine and Hydroxyurea are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Hydroxyurea combined with didanosine has caused pancreatitis, hepatotoxicity including fatal hepatic failure, and peripheral neuropathy in HIV patients. The overlapping toxicities make the combination dangerous.
How serious is the interaction between Didanosine and Hydroxyurea?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose a different antiretroviral. If exposure has occurred, monitor for pancreatitis, liver injury and neuropathy and stop the agents if signs appear.
What other medicines interact with Didanosine?
MediHelp also lists interactions of Didanosine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Hydroxycarbamide, Ribavirin. The full list is on the Didanosine page.
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