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Interações medicamentosas

Disopyramide + Sotalol

Gravidade: Contraindicada

Disopyramide and Sotalol: contraindicated interaction.

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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

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Resumo

Both agents prolong repolarization, and disopyramide also has negative inotropic effects. Combined use substantially raises the risk of torsades de pointes and heart failure worsening.

O que esta interação significa em palavras simples

Disopyramide and Sotalol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Disopyramide belongs to Cardiovascular; Sotalol belongs to Cardiovascular.

Nível de evidência: Moderate

Por que acontece

Additive QT prolongation and additive negative inotropic effect.

O que fazer

Avoid combining class Ia and class III antiarrhythmics; choose one agent and monitor ECG closely during any transition.

O que perguntar ao farmacêutico

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Perguntas frequentes

Can I take Disopyramide with Sotalol?

MediHelp rates the interaction as contraindicated. Disopyramide and Sotalol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both agents prolong repolarization, and disopyramide also has negative inotropic effects. Combined use substantially raises the risk of torsades de pointes and heart failure worsening.

How serious is the interaction between Disopyramide and Sotalol?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining class Ia and class III antiarrhythmics; choose one agent and monitor ECG closely during any transition.

What other medicines interact with Sotalol?

MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Dofetilide. The full list is on the Sotalol page.

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