Interações medicamentosas
Disopyramide + Maprotiline
Gravidade: Contraindicada
Disopyramide and Maprotiline: contraindicated interaction.
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Resumo
Both drugs can prolong the QT interval, and combining them raises the risk of torsades de pointes and other serious ventricular arrhythmias. Maprotiline also has quinidine-like conduction effects, and disopyramide is itself strongly proarrhythmic.
O que esta interação significa em palavras simples
Disopyramide and Maprotiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Disopyramide belongs to Cardiovascular; Maprotiline belongs to Central Nervous System.
Por que acontece
Additive pharmacodynamic QT prolongation and slowed cardiac conduction.
O que fazer
Avoid the combination and choose an antidepressant with lower QT liability if an antiarrhythmic is required. If it cannot be avoided, obtain a baseline ECG, correct potassium and magnesium, and monitor QTc continuously.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Maprotiline
- Arsenic trioxide + Maprotiline Contraindicada
- Dofetilide + Maprotiline Contraindicada
- Ibutilide + Maprotiline Contraindicada
- Isocarboxazid + Maprotiline Contraindicada
- Maprotiline + Methylene blue Contraindicada
- Maprotiline + Phenelzine Contraindicada
Outras interações de Disopyramide
- Amisulpride + Disopyramide Contraindicada
- Desipramine + Disopyramide Contraindicada
- Disopyramide + Dronedarone Contraindicada
- Disopyramide + Itraconazole Contraindicada
- Disopyramide + Ketoconazole Contraindicada
- Disopyramide + Moxifloxacin Contraindicada
Perguntas frequentes
Can I take Disopyramide with Maprotiline?
MediHelp rates the interaction as contraindicated. Disopyramide and Maprotiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs can prolong the QT interval, and combining them raises the risk of torsades de pointes and other serious ventricular arrhythmias. Maprotiline also has quinidine-like conduction effects, and disopyramide is itself strongly proarrhythmic.
How serious is the interaction between Disopyramide and Maprotiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antidepressant with lower QT liability if an antiarrhythmic is required. If it cannot be avoided, obtain a baseline ECG, correct potassium and magnesium, and monitor QTc continuously.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Maprotiline page.
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