Interações medicamentosas
Bupropion + Linezolid
Gravidade: Contraindicada
Bupropion and Linezolid: contraindicated interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Linezolid is a reversible non-selective MAO inhibitor. Bupropion is contraindicated with MAO inhibitors because of the risk of hypertensive reactions, and linezolid may also raise the risk of serotonin toxicity or neurotoxicity. The combination can cause severe adverse reactions.
O que esta interação significa em palavras simples
Bupropion and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Bupropion belongs to Central Nervous System; Linezolid belongs to Anti Bacterial.
Por que acontece
MAO inhibition by linezolid enhances noradrenergic and dopaminergic stimulation from bupropion, with possible serotonergic toxicity.
O que fazer
Avoid; choose an alternative antibiotic. If linezolid is urgent, stop bupropion and monitor closely for hypertension and serotonin toxicity.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Bupropion e Linezolid, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Bupropion
- Bupropion + Isocarboxazid Contraindicada
- Bupropion + Phenelzine Contraindicada
- Bupropion + Rasagiline Contraindicada
- Bupropion + Selegiline Contraindicada
- Bupropion + Selegiline transdermal Contraindicada
- Bupropion + Thioridazine Contraindicada
Outras interações de Linezolid
- Amoxapine + Linezolid Contraindicada
- Atomoxetine + Linezolid Contraindicada
- Benzphetamine + Linezolid Contraindicada
- Brimonidine + Linezolid Contraindicada
- Bupropion-naltrexone + Linezolid Contraindicada
- Buspirone + Linezolid Contraindicada
Perguntas frequentes
Can I take Bupropion with Linezolid?
MediHelp rates the interaction as contraindicated. Bupropion and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Linezolid is a reversible non-selective MAO inhibitor. Bupropion is contraindicated with MAO inhibitors because of the risk of hypertensive reactions, and linezolid may also raise the risk of serotonin toxicity or neurotoxicity. The combination can cause severe adverse reactions.
How serious is the interaction between Bupropion and Linezolid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid; choose an alternative antibiotic. If linezolid is urgent, stop bupropion and monitor closely for hypertension and serotonin toxicity.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Phenelzine, Rasagiline. The full list is on the Bupropion page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
