Interações medicamentosas
Elacestrant + Erythromycin
Gravidade: Grave
Elacestrant and Erythromycin: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Erythromycin, a moderate CYP3A4 inhibitor, can raise elacestrant concentrations and increase its adverse effects. Labeling advises avoiding moderate CYP3A4 inhibitors with elacestrant.
O que esta interação significa em palavras simples
Elacestrant and Erythromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Elacestrant belongs to Oncology; Erythromycin belongs to Anti Bacterial.
Por que acontece
Inhibition of CYP3A4-mediated metabolism of elacestrant increases its exposure.
O que fazer
Avoid concomitant use and choose a non-CYP3A4-inhibiting antibiotic such as azithromycin or doxycycline where appropriate. If unavoidable, monitor for elacestrant adverse effects such as nausea and hepatic enzyme changes.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Erythromycin
- Conivaptan + Erythromycin Contraindicada
- Dihydroergotamine intranasal + Erythromycin Contraindicada
- Dihydroergotamine + Erythromycin Contraindicada
- Domperidone + Erythromycin Contraindicada
- Dronedarone + Erythromycin Contraindicada
- Droperidol + Erythromycin Contraindicada
Outras interações de Elacestrant
Perguntas frequentes
Can I take Elacestrant with Erythromycin?
MediHelp rates the interaction as major. Elacestrant and Erythromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erythromycin, a moderate CYP3A4 inhibitor, can raise elacestrant concentrations and increase its adverse effects. Labeling advises avoiding moderate CYP3A4 inhibitors with elacestrant.
How serious is the interaction between Elacestrant and Erythromycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use and choose a non-CYP3A4-inhibiting antibiotic such as azithromycin or doxycycline where appropriate. If unavoidable, monitor for elacestrant adverse effects such as nausea and hepatic enzyme changes.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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