Interações medicamentosas
Eliglustat + Ketoconazole
Gravidade: Contraindicada
Eliglustat and Ketoconazole: contraindicated interaction.
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Resumo
Ketoconazole substantially increases eliglustat exposure, which can prolong the PR, QTc and QRS intervals and cause arrhythmias. Labeling contraindicates or restricts the combination depending on CYP2D6 metabolizer status.
O que esta interação significa em palavras simples
Eliglustat and Ketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Eliglustat belongs to Miscellaneous; Ketoconazole belongs to Anti Fungals.
Por que acontece
Ketoconazole inhibits CYP3A4 and, to a lesser extent, CYP2D6, the two main pathways for eliglustat clearance.
O que fazer
Avoid in intermediate and poor CYP2D6 metabolizers and when combined with a CYP2D6 inhibitor. In extensive metabolizers, eliglustat dose reduction is required, with ECG monitoring.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Ketoconazole
- Alfuzosin + Ketoconazole Contraindicada
- Alprazolam + Ketoconazole Contraindicada
- Avanafil + Ketoconazole Contraindicada
- Conivaptan + Ketoconazole Contraindicada
- Dihydroergotamine intranasal + Ketoconazole Contraindicada
- Dihydroergotamine + Ketoconazole Contraindicada
Outras interações de Eliglustat
- Amiodarone + Eliglustat Contraindicada
- Clarithromycin + Eliglustat Contraindicada
- Dronedarone + Eliglustat Contraindicada
- Eliglustat + Itraconazole Contraindicada
- Eliglustat + Pimozide Contraindicada
- Eliglustat + Posaconazole Contraindicada
Perguntas frequentes
Can I take Eliglustat with Ketoconazole?
MediHelp rates the interaction as contraindicated. Eliglustat and Ketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketoconazole substantially increases eliglustat exposure, which can prolong the PR, QTc and QRS intervals and cause arrhythmias. Labeling contraindicates or restricts the combination depending on CYP2D6 metabolizer status.
How serious is the interaction between Eliglustat and Ketoconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in intermediate and poor CYP2D6 metabolizers and when combined with a CYP2D6 inhibitor. In extensive metabolizers, eliglustat dose reduction is required, with ECG monitoring.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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