Interações medicamentosas
Eliglustat + Posaconazole
Gravidade: Contraindicada
Eliglustat and Posaconazole: contraindicated interaction.
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Resumo
Posaconazole increases eliglustat concentrations, which may prolong PR, QRS and QT intervals and cause arrhythmias. The effect is greater in CYP2D6 poor or intermediate metabolizers and when a CYP2D6 inhibitor is also taken.
O que esta interação significa em palavras simples
Eliglustat and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Eliglustat belongs to Miscellaneous; Posaconazole belongs to Anti Fungals.
Por que acontece
Posaconazole inhibits CYP3A4, a secondary eliglustat clearance pathway that becomes critical when CYP2D6 activity is low or inhibited.
O que fazer
Avoid in CYP2D6 poor or intermediate metabolizers and with any additional CYP2D6 inhibitor. In extensive metabolizers, follow labeling with a reduced eliglustat dose and ECG monitoring, or choose an alternative antifungal.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Posaconazole
- Artemether + Posaconazole Contraindicada
- Avanafil + Posaconazole Contraindicada
- Cobimetinib + Posaconazole Contraindicada
- Conivaptan + Posaconazole Contraindicada
- Dihydroergotamine intranasal + Posaconazole Contraindicada
- Dihydroergotamine + Posaconazole Contraindicada
Outras interações de Eliglustat
- Amiodarone + Eliglustat Contraindicada
- Clarithromycin + Eliglustat Contraindicada
- Dronedarone + Eliglustat Contraindicada
- Eliglustat + Itraconazole Contraindicada
- Eliglustat + Ketoconazole Contraindicada
- Eliglustat + Pimozide Contraindicada
Perguntas frequentes
Can I take Eliglustat with Posaconazole?
MediHelp rates the interaction as contraindicated. Eliglustat and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Posaconazole increases eliglustat concentrations, which may prolong PR, QRS and QT intervals and cause arrhythmias. The effect is greater in CYP2D6 poor or intermediate metabolizers and when a CYP2D6 inhibitor is also taken.
How serious is the interaction between Eliglustat and Posaconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in CYP2D6 poor or intermediate metabolizers and with any additional CYP2D6 inhibitor. In extensive metabolizers, follow labeling with a reduced eliglustat dose and ECG monitoring, or choose an alternative antifungal.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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