Interações medicamentosas
Eliglustat + Itraconazole
Gravidade: Contraindicada
Eliglustat and Itraconazole: contraindicated interaction.
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Resumo
Itraconazole strongly increases eliglustat exposure, and both can prolong the QT interval. This raises the risk of cardiac conduction abnormalities and arrhythmia.
O que esta interação significa em palavras simples
Eliglustat and Itraconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Eliglustat belongs to Miscellaneous; Itraconazole belongs to Anti Fungals.
Por que acontece
Strong CYP3A4 inhibition raises eliglustat levels, with additive QT prolongation.
O que fazer
Avoid the combination, and especially so in CYP2D6 poor or intermediate metabolizers. Consider an alternative antifungal.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Itraconazole
- Alfuzosin + Itraconazole Contraindicada
- Alprazolam + Itraconazole Contraindicada
- Avanafil + Itraconazole Contraindicada
- Conivaptan + Itraconazole Contraindicada
- Dihydroergotamine intranasal + Itraconazole Contraindicada
- Dihydroergotamine + Itraconazole Contraindicada
Outras interações de Eliglustat
- Amiodarone + Eliglustat Contraindicada
- Clarithromycin + Eliglustat Contraindicada
- Dronedarone + Eliglustat Contraindicada
- Eliglustat + Ketoconazole Contraindicada
- Eliglustat + Pimozide Contraindicada
- Eliglustat + Posaconazole Contraindicada
Perguntas frequentes
Can I take Eliglustat with Itraconazole?
MediHelp rates the interaction as contraindicated. Eliglustat and Itraconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Itraconazole strongly increases eliglustat exposure, and both can prolong the QT interval. This raises the risk of cardiac conduction abnormalities and arrhythmia.
How serious is the interaction between Eliglustat and Itraconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, and especially so in CYP2D6 poor or intermediate metabolizers. Consider an alternative antifungal.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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