Interações medicamentosas
Entrectinib + Netupitant-palonosetron
Gravidade: Grave
Entrectinib and Netupitant-palonosetron: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Netupitant can increase entrectinib concentrations by inhibiting CYP3A4. This may increase toxicities such as QT prolongation, heart failure and CNS effects.
O que esta interação significa em palavras simples
Entrectinib and Netupitant-palonosetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Entrectinib belongs to Oncology; Netupitant-palonosetron belongs to Gastrointestinal Tract.
Por que acontece
CYP3A4 inhibition by netupitant reduces entrectinib metabolism.
O que fazer
Avoid the combination if possible. If necessary, reduce entrectinib to the labeled dose and monitor ECG and adverse effects.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Netupitant-palonosetron
Outras interações de Entrectinib
Perguntas frequentes
Can I take Entrectinib with Netupitant-palonosetron?
MediHelp rates the interaction as major. Entrectinib and Netupitant-palonosetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Netupitant can increase entrectinib concentrations by inhibiting CYP3A4. This may increase toxicities such as QT prolongation, heart failure and CNS effects.
How serious is the interaction between Entrectinib and Netupitant-palonosetron?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If necessary, reduce entrectinib to the labeled dose and monitor ECG and adverse effects.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Apalutamide. The full list is on the Netupitant-palonosetron page.
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