Interações medicamentosas
Enzalutamide + Isavuconazonium
Gravidade: Contraindicada
Enzalutamide and Isavuconazonium: contraindicated interaction.
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Resumo
Isavuconazonium is converted to isavuconazole, a CYP3A4 substrate, and strong inducers markedly reduce its exposure. This can lead to antifungal failure in invasive infections, and labeling contraindicates strong inducers.
O que esta interação significa em palavras simples
Enzalutamide and Isavuconazonium are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Enzalutamide belongs to Endocrine; Isavuconazonium belongs to Anti Fungals.
Por que acontece
Enzalutamide induces CYP3A4 and increases isavuconazole metabolism.
O que fazer
Do not coadminister; use an alternative antifungal such as liposomal amphotericin B or consider switching the antiandrogen. Monitor clinical response if the inducer was recently stopped.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Enzalutamide
- Doravirine + Enzalutamide Contraindicada
- Elbasvir / grazoprevir + Enzalutamide Contraindicada
- Ensitrelvir + Enzalutamide Contraindicada
- Enzalutamide + Fostemsavir Contraindicada
- Enzalutamide + Lenacapavir Contraindicada
- Enzalutamide + Lonafarnib Contraindicada
Outras interações de Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicada
- Apalutamide + Isavuconazonium Contraindicada
- Carbamazepine + Isavuconazonium Contraindicada
- Cisapride + Isavuconazonium Contraindicada
- Efavirenz + Isavuconazonium Contraindicada
- Isavuconazonium + Ketoconazole Contraindicada
Perguntas frequentes
Can I take Enzalutamide with Isavuconazonium?
MediHelp rates the interaction as contraindicated. Enzalutamide and Isavuconazonium are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Isavuconazonium is converted to isavuconazole, a CYP3A4 substrate, and strong inducers markedly reduce its exposure. This can lead to antifungal failure in invasive infections, and labeling contraindicates strong inducers.
How serious is the interaction between Enzalutamide and Isavuconazonium?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative antifungal such as liposomal amphotericin B or consider switching the antiandrogen. Monitor clinical response if the inducer was recently stopped.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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