Interações medicamentosas
Isavuconazonium + Ketoconazole
Gravidade: Contraindicada
Isavuconazonium and Ketoconazole: contraindicated interaction.
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Resumo
Ketoconazole raises isavuconazole concentrations, increasing the risk of adverse effects including hepatotoxicity and QT shortening. Labeling contraindicates strong CYP3A4 inhibitors with isavuconazonium.
O que esta interação significa em palavras simples
Isavuconazonium and Ketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isavuconazonium belongs to Anti Fungals; Ketoconazole belongs to Anti Fungals.
Por que acontece
Ketoconazole inhibits CYP3A4, the main enzyme clearing isavuconazole.
O que fazer
Do not combine; two azole antifungals are not appropriate together. Select a single agent based on the infection being treated.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Ketoconazole
- Alfuzosin + Ketoconazole Contraindicada
- Alprazolam + Ketoconazole Contraindicada
- Avanafil + Ketoconazole Contraindicada
- Conivaptan + Ketoconazole Contraindicada
- Dihydroergotamine intranasal + Ketoconazole Contraindicada
- Dihydroergotamine + Ketoconazole Contraindicada
Outras interações de Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicada
- Apalutamide + Isavuconazonium Contraindicada
- Carbamazepine + Isavuconazonium Contraindicada
- Cisapride + Isavuconazonium Contraindicada
- Efavirenz + Isavuconazonium Contraindicada
- Enzalutamide + Isavuconazonium Contraindicada
Perguntas frequentes
Can I take Isavuconazonium with Ketoconazole?
MediHelp rates the interaction as contraindicated. Isavuconazonium and Ketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketoconazole raises isavuconazole concentrations, increasing the risk of adverse effects including hepatotoxicity and QT shortening. Labeling contraindicates strong CYP3A4 inhibitors with isavuconazonium.
How serious is the interaction between Isavuconazonium and Ketoconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; two azole antifungals are not appropriate together. Select a single agent based on the infection being treated.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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