Interações medicamentosas
Enzalutamide + Lonafarnib
Gravidade: Contraindicada
Enzalutamide and Lonafarnib: contraindicated interaction.
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Resumo
Lonafarnib is a sensitive CYP3A4 substrate, and enzalutamide's strong induction is expected to cut its exposure considerably. This could reduce efficacy, and labeling advises against strong or moderate inducers.
O que esta interação significa em palavras simples
Enzalutamide and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Enzalutamide belongs to Endocrine; Lonafarnib belongs to Miscellaneous.
Por que acontece
CYP3A4 induction by enzalutamide increases lonafarnib metabolism.
O que fazer
Avoid the combination and seek an alternative antiandrogen. Monitor clinical response closely if it cannot be avoided.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Enzalutamide
- Doravirine + Enzalutamide Contraindicada
- Elbasvir / grazoprevir + Enzalutamide Contraindicada
- Ensitrelvir + Enzalutamide Contraindicada
- Enzalutamide + Fostemsavir Contraindicada
- Enzalutamide + Isavuconazonium Contraindicada
- Enzalutamide + Lenacapavir Contraindicada
Outras interações de Lonafarnib
- Alfuzosin + Lonafarnib Contraindicada
- Amobarbital + Lonafarnib Contraindicada
- Apalutamide + Lonafarnib Contraindicada
- Bosentan + Lonafarnib Contraindicada
- Carbamazepine + Lonafarnib Contraindicada
- Clarithromycin + Lonafarnib Contraindicada
Perguntas frequentes
Can I take Enzalutamide with Lonafarnib?
MediHelp rates the interaction as contraindicated. Enzalutamide and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lonafarnib is a sensitive CYP3A4 substrate, and enzalutamide's strong induction is expected to cut its exposure considerably. This could reduce efficacy, and labeling advises against strong or moderate inducers.
How serious is the interaction between Enzalutamide and Lonafarnib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and seek an alternative antiandrogen. Monitor clinical response closely if it cannot be avoided.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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