Interações medicamentosas
Ergotamine + Idelalisib
Gravidade: Contraindicada
Ergotamine and Idelalisib: contraindicated interaction.
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Resumo
Idelalisib is a strong CYP3A inhibitor and is expected to substantially increase ergotamine exposure, risking severe vasospasm and ischemia. Strong CYP3A inhibitors are contraindicated with ergotamine.
O que esta interação significa em palavras simples
Ergotamine and Idelalisib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ergotamine belongs to Central Nervous System; Idelalisib belongs to Oncology.
Por que acontece
Idelalisib strongly inhibits CYP3A4, markedly reducing ergotamine clearance.
O que fazer
Do not co-administer; use a non-ergot migraine therapy during idelalisib treatment.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Ergotamine
- Almotriptan + Ergotamine Contraindicada
- Atazanavir + Ergotamine Contraindicada
- Clarithromycin + Ergotamine Contraindicada
- Cobicistat + Ergotamine Contraindicada
- Darunavir + Ergotamine Contraindicada
- Dihydroergotamine intranasal + Ergotamine Contraindicada
Outras interações de Idelalisib
- Alfuzosin + Idelalisib Contraindicada
- Cisapride + Idelalisib Contraindicada
- Dihydroergotamine + Idelalisib Contraindicada
- Dronedarone + Idelalisib Contraindicada
- Eletriptan + Idelalisib Contraindicada
- Eplerenone + Idelalisib Contraindicada
Perguntas frequentes
Can I take Ergotamine with Idelalisib?
MediHelp rates the interaction as contraindicated. Ergotamine and Idelalisib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Idelalisib is a strong CYP3A inhibitor and is expected to substantially increase ergotamine exposure, risking severe vasospasm and ischemia. Strong CYP3A inhibitors are contraindicated with ergotamine.
How serious is the interaction between Ergotamine and Idelalisib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use a non-ergot migraine therapy during idelalisib treatment.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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