Interações medicamentosas
Erythromycin + Pitavastatin
Gravidade: Grave
Erythromycin and Pitavastatin: major interaction.
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Resumo
Erythromycin raises pitavastatin exposure, which increases the risk of statin-related myopathy and, rarely, rhabdomyolysis. The effect is clinically relevant mainly in patients with renal impairment or other risk factors.
O que esta interação significa em palavras simples
Erythromycin and Pitavastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Erythromycin belongs to Anti Bacterial; Pitavastatin belongs to Cardiovascular.
Por que acontece
Inhibition of OATP1B1-mediated hepatic uptake of pitavastatin by erythromycin, increasing systemic statin concentrations.
O que fazer
Limit pitavastatin to the labeled maximum dose with erythromycin, or use a non-interacting antibiotic or temporarily hold the statin. Advise patients to report unexplained muscle pain or weakness and check CK if symptoms occur.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Erythromycin
- Conivaptan + Erythromycin Contraindicada
- Dihydroergotamine intranasal + Erythromycin Contraindicada
- Dihydroergotamine + Erythromycin Contraindicada
- Domperidone + Erythromycin Contraindicada
- Dronedarone + Erythromycin Contraindicada
- Droperidol + Erythromycin Contraindicada
Outras interações de Pitavastatin
- Cyclosporine + Pitavastatin Contraindicada
- Cyclosporin + Pitavastatin Contraindicada
- Erythromycin base + Pitavastatin Grave
- Erythromycin ethylsuccinate + Pitavastatin Grave
- Erythromycin lactobionate + Pitavastatin Grave
- Erythromycin stearate + Pitavastatin Grave
Perguntas frequentes
Can I take Erythromycin with Pitavastatin?
MediHelp rates the interaction as major. Erythromycin and Pitavastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erythromycin raises pitavastatin exposure, which increases the risk of statin-related myopathy and, rarely, rhabdomyolysis. The effect is clinically relevant mainly in patients with renal impairment or other risk factors.
How serious is the interaction between Erythromycin and Pitavastatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit pitavastatin to the labeled maximum dose with erythromycin, or use a non-interacting antibiotic or temporarily hold the statin. Advise patients to report unexplained muscle pain or weakness and check CK if symptoms occur.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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