Interações medicamentosas
Escitalopram + Isocarboxazid
Gravidade: Contraindicada
Escitalopram and Isocarboxazid: contraindicated interaction.
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Resumo
Isocarboxazid irreversibly inhibits both MAO-A and MAO-B, so adding escitalopram (an SSRI) can allow serotonin to accumulate excessively. Serotonin syndrome (hyperthermia, clonus, agitation, autonomic instability) can be severe or fatal.
O que esta interação significa em palavras simples
Escitalopram and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Escitalopram belongs to Central Nervous System; Isocarboxazid belongs to Central Nervous System.
Por que acontece
Inhibition of monoamine oxidase combined with an SSRI activity leading to excess serotonergic stimulation
O que fazer
Do not co-administer. Allow at least 14 days between stopping either drug and starting the other.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Escitalopram
- Cisapride + Escitalopram Contraindicada
- Citalopram + Escitalopram Contraindicada
- Escitalopram + Methylene blue Contraindicada
- Escitalopram + Phenelzine Contraindicada
- Escitalopram + Pimozide Contraindicada
- Escitalopram + Procarbazine Contraindicada
Outras interações de Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicada
- Amitriptyline + Isocarboxazid Contraindicada
- Amobarbital + Isocarboxazid Contraindicada
- Amoxapine + Isocarboxazid Contraindicada
- Apraclonidine + Isocarboxazid Contraindicada
- Atomoxetine + Isocarboxazid Contraindicada
Perguntas frequentes
Can I take Escitalopram with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Escitalopram and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Isocarboxazid irreversibly inhibits both MAO-A and MAO-B, so adding escitalopram (an SSRI) can allow serotonin to accumulate excessively. Serotonin syndrome (hyperthermia, clonus, agitation, autonomic instability) can be severe or fatal.
How serious is the interaction between Escitalopram and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Allow at least 14 days between stopping either drug and starting the other.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Methylene blue. The full list is on the Escitalopram page.
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