Interações medicamentosas
Dexamethasone + Rilpivirine
Gravidade: Contraindicada
Dexamethasone and Rilpivirine: contraindicated interaction.
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Resumo
Rilpivirine is a CYP3A4 substrate, and repeated dexamethasone dosing may reduce its concentrations, raising the risk of virologic failure and NNRTI resistance. Single-dose dexamethasone is not a concern.
O que esta interação significa em palavras simples
Dexamethasone and Rilpivirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dexamethasone belongs to Endocrine; Rilpivirine belongs to Anti Virals.
Por que acontece
Dexamethasone induces CYP3A4, increasing rilpivirine clearance.
O que fazer
Do not use more than a single dose of systemic dexamethasone with rilpivirine; select an alternative corticosteroid or antiretroviral for longer courses.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicada
- Dexamethasone + Mifepristone Contraindicada
- Dexamethasone + Smallpox vaccine live Contraindicada
- Dexamethasone + Varicella virus vaccine live Contraindicada
- Dexamethasone + Yellow fever vaccine Contraindicada
- Dexamethasone + Zoster vaccine live Contraindicada
Outras interações de Rilpivirine
- Carbamazepine + Rilpivirine Contraindicada
- Dexlansoprazole + Rilpivirine Contraindicada
- Efavirenz + Rilpivirine Contraindicada
- Eslicarbazepine + Rilpivirine Contraindicada
- Esomeprazole + Rilpivirine Contraindicada
- Lansoprazole + Rilpivirine Contraindicada
Perguntas frequentes
Can I take Dexamethasone with Rilpivirine?
MediHelp rates the interaction as contraindicated. Dexamethasone and Rilpivirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rilpivirine is a CYP3A4 substrate, and repeated dexamethasone dosing may reduce its concentrations, raising the risk of virologic failure and NNRTI resistance. Single-dose dexamethasone is not a concern.
How serious is the interaction between Dexamethasone and Rilpivirine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use more than a single dose of systemic dexamethasone with rilpivirine; select an alternative corticosteroid or antiretroviral for longer courses.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Smallpox vaccine live. The full list is on the Dexamethasone page.
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