Interações medicamentosas
Ethambutol + Probenecid
Gravidade: Moderada
Ethambutol and Probenecid: moderate interaction.
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Resumo
Ethambutol reduces renal urate excretion and can cause hyperuricemia or provoke gout. This opposes the urate-lowering effect of probenecid and may require adjustment of gout therapy.
O que esta interação significa em palavras simples
Ethambutol and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethambutol belongs to Anti Bacterial; Probenecid belongs to Genitourinary.
Por que acontece
Ethambutol decreases renal tubular urate excretion, pharmacodynamically antagonizing the uricosuric action of probenecid.
O que fazer
Monitor serum uric acid and gout symptoms during ethambutol treatment. Increase the uricosuric dose or switch to another urate-lowering agent if control is lost.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Probenecid
- Ketorolac intranasal + Probenecid Contraindicada
- Ketorolac + Probenecid Contraindicada
- Baricitinib + Probenecid Grave
- Ceftazidime / avibactam + Probenecid Grave
- Methotrexate + Probenecid Grave
- Pralatrexate + Probenecid Grave
Outras interações de Ethambutol
Perguntas frequentes
Can I take Ethambutol with Probenecid?
MediHelp rates the interaction as moderate. Ethambutol and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethambutol reduces renal urate excretion and can cause hyperuricemia or provoke gout. This opposes the urate-lowering effect of probenecid and may require adjustment of gout therapy.
How serious is the interaction between Ethambutol and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum uric acid and gout symptoms during ethambutol treatment. Increase the uricosuric dose or switch to another urate-lowering agent if control is lost.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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