Interações medicamentosas
Etoposide + Olaparib
Gravidade: Grave
Etoposide and Olaparib: major interaction.
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Resumo
Both drugs cause bone marrow suppression, so the combination can intensify and prolong cytopenias. Anemia, neutropenia and thrombocytopenia are of particular concern.
O que esta interação significa em palavras simples
Etoposide and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etoposide belongs to Oncology; Olaparib belongs to Oncology.
Por que acontece
Additive myelosuppression from topoisomerase II inhibition and PARP inhibition with impaired DNA repair.
O que fazer
Monitor complete blood counts frequently and reduce doses or delay cycles as needed. Provide supportive care such as growth factors per guidelines.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicada
- Etoposide + Pentostatin Contraindicada
- Cyclosporine + Etoposide Grave
- Cyclosporin + Etoposide Grave
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Grave
- Etoposide + Fingolimod Grave
Outras interações de Olaparib
- Amiodarone + Olaparib Grave
- Amobarbital + Olaparib Grave
- Apalutamide + Olaparib Grave
- Aprepitant + Olaparib Grave
- Azathioprine + Olaparib Grave
- Carbamazepine + Olaparib Grave
Perguntas frequentes
Can I take Etoposide with Olaparib?
MediHelp rates the interaction as major. Etoposide and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs cause bone marrow suppression, so the combination can intensify and prolong cytopenias. Anemia, neutropenia and thrombocytopenia are of particular concern.
How serious is the interaction between Etoposide and Olaparib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and reduce doses or delay cycles as needed. Provide supportive care such as growth factors per guidelines.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporine. The full list is on the Etoposide page.
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