Interações medicamentosas
Etoricoxib + Venlafaxine
Gravidade: Moderada
Etoricoxib and Venlafaxine: moderate interaction.
Última atualização Fontes: US FDA label
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Resumo
Venlafaxine and NSAIDs including selective COX-2 inhibitors such as etoricoxib each increase the risk of bleeding, and together the risk of gastrointestinal and other haemorrhage is higher. The absolute risk is modest in healthy patients but meaningful in older adults and those with prior ulcers. Etoricoxib may carry less gastric toxicity than non-selective NSAIDs but does not remove this risk.
O que esta interação significa em palavras simples
Etoricoxib and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etoricoxib belongs to Musculoskeletal; Venlafaxine belongs to Central Nervous System.
Por que acontece
Venlafaxine inhibits serotonin reuptake into platelets, depleting platelet serotonin and impairing aggregation, while NSAIDs add mucosal injury and effects on haemostasis. Etoricoxib may also raise blood pressure, which venlafaxine can also do.
O que fazer
Use the lowest effective etoricoxib dose for the shortest duration, and consider a PPI in patients with risk factors for GI bleeding. Monitor for bruising, melaena, haematemesis and check blood count if use is prolonged.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Referências
- Effexor XR (venlafaxine) Prescribing Information - Warnings and Precautions: Abnormal Bleeding — FDA Label
- Arcoxia (etoricoxib) Summary of Product Characteristics — EMA SmPC
Outras interações de Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicada
- Methylene blue + Venlafaxine Contraindicada
- Phenelzine + Venlafaxine Contraindicada
- Procarbazine + Venlafaxine Contraindicada
- Rasagiline + Venlafaxine Contraindicada
- Safinamide + Venlafaxine Contraindicada
Perguntas frequentes
Can I take Etoricoxib with Venlafaxine?
MediHelp rates the interaction as moderate. Etoricoxib and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venlafaxine and NSAIDs including selective COX-2 inhibitors such as etoricoxib each increase the risk of bleeding, and together the risk of gastrointestinal and other haemorrhage is higher. The absolute risk is modest in healthy patients but meaningful in older adults and those with prior ulcers. Etoricoxib may carry less gastric toxicity than non-selective NSAIDs but does not remove this risk.
How serious is the interaction between Etoricoxib and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective etoricoxib dose for the shortest duration, and consider a PPI in patients with risk factors for GI bleeding. Monitor for bruising, melaena, haematemesis and check blood count if use is prolonged.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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