Interações medicamentosas
Flecainide + Thioridazine
Gravidade: Contraindicada
Flecainide and Thioridazine: contraindicated interaction.
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Resumo
Thioridazine markedly prolongs the QT interval, and inhibits CYP2D6, which can raise flecainide levels. The combination carries a high risk of torsades de pointes and sudden cardiac death.
O que esta interação significa em palavras simples
Flecainide and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Flecainide belongs to Cardiovascular; Thioridazine belongs to Central Nervous System.
Por que acontece
Additive QT prolongation and conduction effects plus CYP2D6 inhibition by thioridazine reducing flecainide clearance.
O que fazer
Do not use together; choose a different antipsychotic with lower QT liability. If a patient is already on both, stop one under cardiac monitoring.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Flecainide
- Flecainide + Nirmatrelvir Contraindicada
- Flecainide + Nirmatrelvir / ritonavir Contraindicada
- Flecainide + Pimozide Contraindicada
- Flecainide + Ritonavir Contraindicada
- Flecainide + Tipranavir Contraindicada
- Flecainide + Vandetanib Contraindicada
Outras interações de Thioridazine
- Abiraterone + Thioridazine Contraindicada
- Adagrasib + Thioridazine Contraindicada
- Amiodarone + Thioridazine Contraindicada
- Amisulpride + Thioridazine Contraindicada
- Amitriptyline + Thioridazine Contraindicada
- Amoxapine + Thioridazine Contraindicada
Perguntas frequentes
Can I take Flecainide with Thioridazine?
MediHelp rates the interaction as contraindicated. Flecainide and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine markedly prolongs the QT interval, and inhibits CYP2D6, which can raise flecainide levels. The combination carries a high risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Flecainide and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose a different antipsychotic with lower QT liability. If a patient is already on both, stop one under cardiac monitoring.
What other medicines interact with Flecainide?
MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir, Nirmatrelvir / ritonavir, Pimozide. The full list is on the Flecainide page.
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