Interações medicamentosas
Folic acid + Fosphenytoin
Gravidade: Moderada
Folic acid and Fosphenytoin: moderate interaction.
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Resumo
Folic acid supplementation can lower phenytoin concentrations, which are the active form of fosphenytoin, and may lead to loss of seizure control. The effect is more likely with higher folate doses.
O que esta interação significa em palavras simples
Folic acid and Fosphenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Folic acid belongs to Miscellaneous; Fosphenytoin belongs to Central Nervous System.
Por que acontece
Folate may increase phenytoin metabolism; the exact mechanism is not firmly established.
O que fazer
Monitor phenytoin levels and seizure frequency when folic acid is started or changed. Adjust the fosphenytoin dose as needed.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Folic acid
- Ethotoin + Folic acid Moderada
- Folic acid + Glucarpidase Moderada
- Folic acid + Methotrexate Moderada
- Folic acid + Pafolacianine Moderada
- Folic acid + Phenobarbital Moderada
- Folic acid + Phenytoin Moderada
Outras interações de Fosphenytoin
- Dronedarone + Fosphenytoin Contraindicada
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicada
- Fosphenytoin + Lorlatinib Contraindicada
- Fosphenytoin + Lurasidone Contraindicada
- Fosphenytoin + Ranolazine Contraindicada
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicada
Perguntas frequentes
Can I take Folic acid with Fosphenytoin?
MediHelp rates the interaction as moderate. Folic acid and Fosphenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Folic acid supplementation can lower phenytoin concentrations, which are the active form of fosphenytoin, and may lead to loss of seizure control. The effect is more likely with higher folate doses.
How serious is the interaction between Folic acid and Fosphenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor phenytoin levels and seizure frequency when folic acid is started or changed. Adjust the fosphenytoin dose as needed.
What other medicines interact with Folic acid?
MediHelp also lists interactions of Folic acid with, for example, Ethotoin, Glucarpidase, Methotrexate. The full list is on the Folic acid page.
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