Interações medicamentosas
Folic acid + Phenytoin
Gravidade: Moderada
Folic acid and Phenytoin: moderate interaction.
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Resumo
Folic acid, especially at high doses, can lower serum phenytoin levels and has been linked with reduced seizure control. Phenytoin can also lower folate levels, so supplementation is often needed.
O que esta interação significa em palavras simples
Folic acid and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Folic acid belongs to Miscellaneous; Phenytoin belongs to Central Nervous System.
Por que acontece
Folate may increase the hepatic metabolism of phenytoin, while phenytoin impairs folate absorption and status.
O que fazer
Monitor phenytoin levels and seizure frequency when starting or adjusting folic acid. Adjust the phenytoin dose if levels fall.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicada
- Bictegravir + Phenytoin Contraindicada
- Cabotegravir + Phenytoin Contraindicada
- Doravirine + Phenytoin Contraindicada
- Elbasvir / grazoprevir + Phenytoin Contraindicada
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicada
Outras interações de Folic acid
- Ethotoin + Folic acid Moderada
- Folic acid + Fosphenytoin Moderada
- Folic acid + Glucarpidase Moderada
- Folic acid + Methotrexate Moderada
- Folic acid + Pafolacianine Moderada
- Folic acid + Phenobarbital Moderada
Perguntas frequentes
Can I take Folic acid with Phenytoin?
MediHelp rates the interaction as moderate. Folic acid and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Folic acid, especially at high doses, can lower serum phenytoin levels and has been linked with reduced seizure control. Phenytoin can also lower folate levels, so supplementation is often needed.
How serious is the interaction between Folic acid and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor phenytoin levels and seizure frequency when starting or adjusting folic acid. Adjust the phenytoin dose if levels fall.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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