Interações medicamentosas
Hydroxycarbamide + Stavudine
Gravidade: Contraindicada
Hydroxycarbamide and Stavudine: contraindicated interaction.
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Resumo
Hydroxycarbamide with stavudine has been linked to fatal and nonfatal pancreatitis, hepatotoxicity and severe peripheral neuropathy. Hepatic failure and lactic acidosis are also of concern.
O que esta interação significa em palavras simples
Hydroxycarbamide and Stavudine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Hydroxycarbamide belongs to Oncology; Stavudine belongs to Anti Virals.
Por que acontece
Additive mitochondrial and organ toxicity, with hydroxycarbamide possibly increasing stavudine-related toxicity.
O que fazer
Do not combine; switch to a safer antiretroviral regimen. Monitor liver enzymes, lipase and neuropathy symptoms if exposure has occurred.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Hydroxycarbamide
- Didanosine + Hydroxycarbamide Contraindicada
Outras interações de Stavudine
- Didanosine + Stavudine Contraindicada
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Stavudine Contraindicada
- Stavudine + Zidovudine Contraindicada
- Atidarsagene autotemcel + Stavudine Grave
- Betibeglogene autotemcel + Stavudine Grave
- Elivaldogene autotemcel + Stavudine Grave
Perguntas frequentes
Can I take Hydroxycarbamide with Stavudine?
MediHelp rates the interaction as contraindicated. Hydroxycarbamide and Stavudine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Hydroxycarbamide with stavudine has been linked to fatal and nonfatal pancreatitis, hepatotoxicity and severe peripheral neuropathy. Hepatic failure and lactic acidosis are also of concern.
How serious is the interaction between Hydroxycarbamide and Stavudine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; switch to a safer antiretroviral regimen. Monitor liver enzymes, lipase and neuropathy symptoms if exposure has occurred.
What other medicines interact with Hydroxycarbamide?
MediHelp also lists interactions of Hydroxycarbamide with, for example, Didanosine. The full list is on the Hydroxycarbamide page.
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