Interações medicamentosas
Hydroxychloroquine + Pimozide
Gravidade: Contraindicada
Hydroxychloroquine and Pimozide: contraindicated interaction.
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Resumo
Pimozide has a marked QT-prolonging effect and hydroxychloroquine adds to this, increasing the chance of torsades de pointes and sudden cardiac death. Pimozide labeling cautions against combination with other QT-prolonging drugs.
O que esta interação significa em palavras simples
Hydroxychloroquine and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Hydroxychloroquine belongs to Musculoskeletal; Pimozide belongs to Central Nervous System.
Por que acontece
Additive QT prolongation via hERG potassium channel blockade.
O que fazer
Do not co-administer; select an alternative antimalarial or antirheumatic agent, or a different antipsychotic, in place of one of the two.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicada
- Cisapride + Hydroxychloroquine Contraindicada
- Dronedarone + Hydroxychloroquine Contraindicada
- Hydroxychloroquine + Thioridazine Contraindicada
- Hydroxychloroquine + Vandetanib Contraindicada
- Adagrasib + Hydroxychloroquine Grave
Outras interações de Pimozide
- Adagrasib + Pimozide Contraindicada
- Amiodarone + Pimozide Contraindicada
- Amisulpride + Pimozide Contraindicada
- Amitriptyline + Pimozide Contraindicada
- Amoxapine + Pimozide Contraindicada
- Anagrelide + Pimozide Contraindicada
Perguntas frequentes
Can I take Hydroxychloroquine with Pimozide?
MediHelp rates the interaction as contraindicated. Hydroxychloroquine and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Pimozide has a marked QT-prolonging effect and hydroxychloroquine adds to this, increasing the chance of torsades de pointes and sudden cardiac death. Pimozide labeling cautions against combination with other QT-prolonging drugs.
How serious is the interaction between Hydroxychloroquine and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; select an alternative antimalarial or antirheumatic agent, or a different antipsychotic, in place of one of the two.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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