Interações medicamentosas
Imipenem / cilastatin / relebactam + Valacyclovir
Gravidade: Moderada
Imipenem / cilastatin / relebactam and Valacyclovir: moderate interaction.
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Resumo
Imipenem-containing therapy can lower the seizure threshold, and valacyclovir neurotoxicity occurs especially in renal impairment. Combined use may add to seizure risk, though evidence is limited.
O que esta interação significa em palavras simples
Imipenem / cilastatin / relebactam and Valacyclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Por que acontece
Possible additive neurotoxicity; no established mechanism for the combination.
O que fazer
Dose both drugs according to renal function and monitor for neurological symptoms. Consider alternatives in patients with seizure history.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Valacyclovir
Perguntas frequentes
Can I take Imipenem / cilastatin / relebactam with Valacyclovir?
MediHelp rates the interaction as moderate. Imipenem / cilastatin / relebactam and Valacyclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imipenem-containing therapy can lower the seizure threshold, and valacyclovir neurotoxicity occurs especially in renal impairment. Combined use may add to seizure risk, though evidence is limited.
How serious is the interaction between Imipenem / cilastatin / relebactam and Valacyclovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Dose both drugs according to renal function and monitor for neurological symptoms. Consider alternatives in patients with seizure history.
What other medicines interact with Valacyclovir?
MediHelp also lists interactions of Valacyclovir with, for example, Talimogene laherparepvec, Bacitracin, Cilastatin-imipenem. The full list is on the Valacyclovir page.
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