Interações medicamentosas
Talimogene laherparepvec + Valacyclovir
Gravidade: Grave
Talimogene laherparepvec and Valacyclovir: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Talimogene laherparepvec is a live attenuated herpes simplex virus that must replicate to be effective. Antiherpetic antivirals may suppress its replication and reduce efficacy.
O que esta interação significa em palavras simples
Talimogene laherparepvec and Valacyclovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Talimogene laherparepvec belongs to Oncology; Valacyclovir belongs to Anti Virals.
Por que acontece
Valacyclovir's active form acyclovir inhibits herpes viral DNA polymerase, which may block replication of the oncolytic virus.
O que fazer
Avoid antiherpetic agents during talimogene therapy unless needed to treat herpetic infection. Review the need for valacyclovir before each treatment.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Valacyclovir
- Bacitracin + Valacyclovir Moderada
- Cilastatin-imipenem + Valacyclovir Moderada
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Valacyclovir Moderada
- Imipenem / cilastatin / relebactam + Valacyclovir Moderada
- Imipenem / cilastatin + Valacyclovir Moderada
- Mycophenolic acid + Valacyclovir Moderada
Outras interações de Talimogene laherparepvec
Perguntas frequentes
Can I take Talimogene laherparepvec with Valacyclovir?
MediHelp rates the interaction as major. Talimogene laherparepvec and Valacyclovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Talimogene laherparepvec is a live attenuated herpes simplex virus that must replicate to be effective. Antiherpetic antivirals may suppress its replication and reduce efficacy.
How serious is the interaction between Talimogene laherparepvec and Valacyclovir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid antiherpetic agents during talimogene therapy unless needed to treat herpetic infection. Review the need for valacyclovir before each treatment.
What other medicines interact with Valacyclovir?
MediHelp also lists interactions of Valacyclovir with, for example, Bacitracin, Cilastatin-imipenem, Elvitegravir / cobicistat / emtricitabine / tenofovir df. The full list is on the Valacyclovir page.
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