Interações medicamentosas
Cilastatin-imipenem + Valacyclovir
Gravidade: Moderada
Cilastatin-imipenem and Valacyclovir: moderate interaction.
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Resumo
Seizures have been reported when ganciclovir is combined with imipenem-cilastatin, and valacyclovir's active metabolite acyclovir may carry a similar though less documented concern. Both drug classes can lower seizure threshold, especially in renal impairment.
O que esta interação significa em palavras simples
Cilastatin-imipenem and Valacyclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilastatin-imipenem belongs to Anti Bacterial; Valacyclovir belongs to Anti Virals.
Por que acontece
The mechanism is not established and is likely additive lowering of seizure threshold.
O que fazer
Dose-adjust both drugs for renal function and monitor for confusion, myoclonus or seizures. Consider alternatives in patients with a seizure history.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Cilastatin-imipenem
Outras interações de Valacyclovir
- Talimogene laherparepvec + Valacyclovir Grave
- Bacitracin + Valacyclovir Moderada
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Valacyclovir Moderada
- Imipenem / cilastatin / relebactam + Valacyclovir Moderada
- Imipenem / cilastatin + Valacyclovir Moderada
- Mycophenolic acid + Valacyclovir Moderada
Perguntas frequentes
Can I take Cilastatin-imipenem with Valacyclovir?
MediHelp rates the interaction as moderate. Cilastatin-imipenem and Valacyclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Seizures have been reported when ganciclovir is combined with imipenem-cilastatin, and valacyclovir's active metabolite acyclovir may carry a similar though less documented concern. Both drug classes can lower seizure threshold, especially in renal impairment.
How serious is the interaction between Cilastatin-imipenem and Valacyclovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Dose-adjust both drugs for renal function and monitor for confusion, myoclonus or seizures. Consider alternatives in patients with a seizure history.
What other medicines interact with Cilastatin-imipenem?
MediHelp also lists interactions of Cilastatin-imipenem with, for example, Divalproex, Ganciclovir, Valproic acid. The full list is on the Cilastatin-imipenem page.
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