Interações medicamentosas
Mycophenolic acid + Valacyclovir
Gravidade: Moderada
Mycophenolic acid and Valacyclovir: moderate interaction.
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Resumo
Valacyclovir is converted to acyclovir, which competes with mycophenolate glucuronide for renal tubular secretion. Both may accumulate, particularly with reduced kidney function, raising the risk of neutropenia or neurotoxicity.
O que esta interação significa em palavras simples
Mycophenolic acid and Valacyclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mycophenolic acid belongs to Miscellaneous; Valacyclovir belongs to Anti Virals.
Por que acontece
Competition between acyclovir and MPA glucuronide for renal tubular secretion.
O que fazer
Monitor complete blood counts and renal function. Reduce doses if cytopenias or renal impairment occur.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Mycophenolic acid
Outras interações de Valacyclovir
- Talimogene laherparepvec + Valacyclovir Grave
- Bacitracin + Valacyclovir Moderada
- Cilastatin-imipenem + Valacyclovir Moderada
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Valacyclovir Moderada
- Imipenem / cilastatin / relebactam + Valacyclovir Moderada
- Imipenem / cilastatin + Valacyclovir Moderada
Perguntas frequentes
Can I take Mycophenolic acid with Valacyclovir?
MediHelp rates the interaction as moderate. Mycophenolic acid and Valacyclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valacyclovir is converted to acyclovir, which competes with mycophenolate glucuronide for renal tubular secretion. Both may accumulate, particularly with reduced kidney function, raising the risk of neutropenia or neurotoxicity.
How serious is the interaction between Mycophenolic acid and Valacyclovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and renal function. Reduce doses if cytopenias or renal impairment occur.
What other medicines interact with Mycophenolic acid?
MediHelp also lists interactions of Mycophenolic acid with, for example, Activated charcoal, Azathioprine, Cholestyramine. The full list is on the Mycophenolic acid page.
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