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Interações medicamentosas

Influenza virus vaccine quadrivalent intranasal + Mercaptopurine

Gravidade: Contraindicada

Influenza virus vaccine quadrivalent intranasal and Mercaptopurine: contraindicated interaction.

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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

O conteúdo clínico desta página está disponível apenas em inglês.

Resumo

The intranasal vaccine contains live attenuated virus, which may replicate more in immunosuppressed patients. Mercaptopurine also may reduce the immune response.

O que esta interação significa em palavras simples

Influenza virus vaccine quadrivalent intranasal and Mercaptopurine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Nível de evidência: Moderate

Por que acontece

Immunosuppression impairs control of live attenuated virus replication.

O que fazer

Avoid the live intranasal vaccine in patients on mercaptopurine and use an inactivated injectable influenza vaccine instead.

O que perguntar ao farmacêutico

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Perguntas frequentes

Can I take Influenza virus vaccine quadrivalent intranasal with Mercaptopurine?

MediHelp rates the interaction as contraindicated. Influenza virus vaccine quadrivalent intranasal and Mercaptopurine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The intranasal vaccine contains live attenuated virus, which may replicate more in immunosuppressed patients. Mercaptopurine also may reduce the immune response.

How serious is the interaction between Influenza virus vaccine quadrivalent intranasal and Mercaptopurine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the live intranasal vaccine in patients on mercaptopurine and use an inactivated injectable influenza vaccine instead.

What other medicines interact with Mercaptopurine?

MediHelp also lists interactions of Mercaptopurine with, for example, Adenovirus types 4 and 7 live, Azathioprine, Bcg vaccine live. The full list is on the Mercaptopurine page.

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