Interações medicamentosas
Azathioprine + Mercaptopurine
Gravidade: Contraindicada
Azathioprine and Mercaptopurine: contraindicated interaction.
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Resumo
Azathioprine is converted in the body to mercaptopurine, so giving both drugs duplicates the same active thiopurine exposure. This raises the risk of profound myelosuppression, serious infection and hepatotoxicity.
O que esta interação significa em palavras simples
Azathioprine and Mercaptopurine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Azathioprine belongs to Gastrointestinal Tract; Mercaptopurine belongs to Oncology.
Por que acontece
Therapeutic duplication: azathioprine is a prodrug of mercaptopurine, so both generate the same cytotoxic thioguanine nucleotides.
O que fazer
Do not combine the two drugs; use only one thiopurine at a time. If switching, stop one before starting the other and monitor blood counts.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Mercaptopurine
- Adenovirus types 4 and 7 live + Mercaptopurine Contraindicada
- Bcg vaccine live + Mercaptopurine Contraindicada
- Febuxostat + Mercaptopurine Contraindicada
- Influenza virus vaccine quadrivalent intranasal + Mercaptopurine Contraindicada
- Mercaptopurine + Smallpox vaccine live Contraindicada
- Adalimumab + Mercaptopurine Grave
Outras interações de Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Contraindicada
- Azathioprine + Bcg vaccine live Contraindicada
- Azathioprine + Febuxostat Contraindicada
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Contraindicada
- Azathioprine + Measles mumps and rubella vaccine Contraindicada
- Azathioprine + Measles mumps and rubella vaccine live Contraindicada
Perguntas frequentes
Can I take Azathioprine with Mercaptopurine?
MediHelp rates the interaction as contraindicated. Azathioprine and Mercaptopurine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Azathioprine is converted in the body to mercaptopurine, so giving both drugs duplicates the same active thiopurine exposure. This raises the risk of profound myelosuppression, serious infection and hepatotoxicity.
How serious is the interaction between Azathioprine and Mercaptopurine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine the two drugs; use only one thiopurine at a time. If switching, stop one before starting the other and monitor blood counts.
What other medicines interact with Mercaptopurine?
MediHelp also lists interactions of Mercaptopurine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Mercaptopurine page.
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