Interações medicamentosas
Mercaptopurine + Smallpox vaccine live
Gravidade: Contraindicada
Mercaptopurine and Smallpox vaccine live: contraindicated interaction.
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Resumo
Live vaccinia vaccine can cause progressive vaccinia and generalized infection in immunosuppressed people. Mercaptopurine increases this risk and reduces the protective response.
O que esta interação significa em palavras simples
Mercaptopurine and Smallpox vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Immunosuppression from a purine antimetabolite permits uncontrolled replication of vaccinia virus and impairs immune response.
O que fazer
Avoid live smallpox vaccine in patients on mercaptopurine except in a true exposure emergency under specialist guidance. A non-replicating alternative should be considered where available.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Mercaptopurine
- Adenovirus types 4 and 7 live + Mercaptopurine Contraindicada
- Azathioprine + Mercaptopurine Contraindicada
- Bcg vaccine live + Mercaptopurine Contraindicada
- Febuxostat + Mercaptopurine Contraindicada
- Influenza virus vaccine quadrivalent intranasal + Mercaptopurine Contraindicada
- Adalimumab + Mercaptopurine Grave
Perguntas frequentes
Can I take Mercaptopurine with Smallpox vaccine live?
MediHelp rates the interaction as contraindicated. Mercaptopurine and Smallpox vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Live vaccinia vaccine can cause progressive vaccinia and generalized infection in immunosuppressed people. Mercaptopurine increases this risk and reduces the protective response.
How serious is the interaction between Mercaptopurine and Smallpox vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live smallpox vaccine in patients on mercaptopurine except in a true exposure emergency under specialist guidance. A non-replicating alternative should be considered where available.
What other medicines interact with Mercaptopurine?
MediHelp also lists interactions of Mercaptopurine with, for example, Adenovirus types 4 and 7 live, Azathioprine, Bcg vaccine live. The full list is on the Mercaptopurine page.
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