Interações medicamentosas
Insulin degludec + Rosiglitazone
Gravidade: Grave
Insulin degludec and Rosiglitazone: major interaction.
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Resumo
Rosiglitazone improves insulin sensitivity and enhances insulin's glucose-lowering effect, increasing hypoglycemia risk. Combination with insulin has also been associated with fluid retention, heart failure and possibly myocardial ischemia.
O que esta interação significa em palavras simples
Insulin degludec and Rosiglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Insulin degludec belongs to Endocrine; Rosiglitazone belongs to Endocrine.
Por que acontece
Additive glucose lowering from insulin sensitization plus exogenous insulin; fluid retention is also additive.
O que fazer
Monitor blood glucose and reduce the insulin dose as needed. Monitor for edema and heart failure signs, and avoid in patients with heart failure or high cardiovascular risk.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Insulin degludec
Outras interações de Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Grave
- Insulin aspart-insulin aspart protamine + Rosiglitazone Grave
- Insulin aspart + Rosiglitazone Grave
- Insulin degludec / insulin aspart + Rosiglitazone Grave
- Insulin degludec-insulin aspart + Rosiglitazone Grave
- Insulin degludec-liraglutide + Rosiglitazone Grave
Perguntas frequentes
Can I take Insulin degludec with Rosiglitazone?
MediHelp rates the interaction as major. Insulin degludec and Rosiglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rosiglitazone improves insulin sensitivity and enhances insulin's glucose-lowering effect, increasing hypoglycemia risk. Combination with insulin has also been associated with fluid retention, heart failure and possibly myocardial ischemia.
How serious is the interaction between Insulin degludec and Rosiglitazone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and reduce the insulin dose as needed. Monitor for edema and heart failure signs, and avoid in patients with heart failure or high cardiovascular risk.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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