Interações medicamentosas
Insulin degludec-insulin aspart + Rosiglitazone
Gravidade: Grave
Insulin degludec-insulin aspart and Rosiglitazone: major interaction.
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Resumo
Rosiglitazone combined with insulin increases glucose lowering and the risk of hypoglycemia. The combination markedly raises the risk of edema and heart failure, and labeling advises against its use with insulin.
O que esta interação significa em palavras simples
Insulin degludec-insulin aspart and Rosiglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Insulin degludec-insulin aspart belongs to Endocrine; Rosiglitazone belongs to Endocrine.
Por que acontece
Rosiglitazone increases insulin sensitivity and causes fluid retention, adding to insulin effect and cardiac volume load.
O que fazer
Avoid combining where possible; if used, reduce insulin as needed and monitor for edema, weight gain and heart failure.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Grave
- Clozapine + Insulin degludec-insulin aspart Grave
- Diazoxide + Insulin degludec-insulin aspart Grave
- Ethanol + Insulin degludec-insulin aspart Grave
- Insulin degludec-insulin aspart + Mecasermin Grave
- Insulin degludec-insulin aspart + Pioglitazone Grave
Outras interações de Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Grave
- Insulin aspart-insulin aspart protamine + Rosiglitazone Grave
- Insulin aspart + Rosiglitazone Grave
- Insulin degludec / insulin aspart + Rosiglitazone Grave
- Insulin degludec-liraglutide + Rosiglitazone Grave
- Insulin degludec + Rosiglitazone Grave
Perguntas frequentes
Can I take Insulin degludec-insulin aspart with Rosiglitazone?
MediHelp rates the interaction as major. Insulin degludec-insulin aspart and Rosiglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rosiglitazone combined with insulin increases glucose lowering and the risk of hypoglycemia. The combination markedly raises the risk of edema and heart failure, and labeling advises against its use with insulin.
How serious is the interaction between Insulin degludec-insulin aspart and Rosiglitazone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if used, reduce insulin as needed and monitor for edema, weight gain and heart failure.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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