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Interações medicamentosas

Isotretinoin + Vitamin a

Gravidade: Grave

Isotretinoin and Vitamin a: major interaction.

Última atualização Fontes: US FDA label

Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

O conteúdo clínico desta página está disponível apenas em inglês.

Resumo

Isotretinoin is a vitamin A derivative, and supplemental vitamin A adds to the retinoid load. This can produce signs of hypervitaminosis A such as headache, raised intracranial pressure, dry skin, liver toxicity and bone effects.

O que esta interação significa em palavras simples

Isotretinoin and Vitamin a can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Isotretinoin belongs to Dermatology; Vitamin a belongs to Gastrointestinal Tract.

Nível de evidência: High

Por que acontece

Additive retinoid pharmacodynamic effects leading to hypervitaminosis A-type toxicity.

O que fazer

Avoid vitamin A supplements during isotretinoin therapy, including multivitamins with high vitamin A content. Review supplement use at each visit.

O que perguntar ao farmacêutico

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Referências

Perguntas frequentes

Can I take Isotretinoin with Vitamin a?

MediHelp rates the interaction as major. Isotretinoin and Vitamin a can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Isotretinoin is a vitamin A derivative, and supplemental vitamin A adds to the retinoid load. This can produce signs of hypervitaminosis A such as headache, raised intracranial pressure, dry skin, liver toxicity and bone effects.

How serious is the interaction between Isotretinoin and Vitamin a?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid vitamin A supplements during isotretinoin therapy, including multivitamins with high vitamin A content. Review supplement use at each visit.

What other medicines interact with Isotretinoin?

MediHelp also lists interactions of Isotretinoin with, for example, Demeclocycline, Minocycline, Oxytetracycline. The full list is on the Isotretinoin page.

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