Interações medicamentosas
Itraconazole + Voclosporin
Gravidade: Contraindicada
Itraconazole and Voclosporin: contraindicated interaction.
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Resumo
Itraconazole markedly raises voclosporin levels, increasing risks of nephrotoxicity, hypertension, neurotoxicity and QT prolongation. Voclosporin labeling contraindicates strong CYP3A4 inhibitors.
O que esta interação significa em palavras simples
Itraconazole and Voclosporin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Itraconazole belongs to Anti Fungals; Voclosporin belongs to Miscellaneous.
Por que acontece
Strong CYP3A4 inhibition by itraconazole reduces metabolism of voclosporin, with possible additive QT effects.
O que fazer
Avoid the combination and use an alternative antifungal with less CYP3A4 inhibition, monitoring renal function if unavoidable exposure occurs.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Itraconazole
- Alfuzosin + Itraconazole Contraindicada
- Alprazolam + Itraconazole Contraindicada
- Avanafil + Itraconazole Contraindicada
- Conivaptan + Itraconazole Contraindicada
- Dihydroergotamine intranasal + Itraconazole Contraindicada
- Dihydroergotamine + Itraconazole Contraindicada
Outras interações de Voclosporin
- Clarithromycin + Voclosporin Contraindicada
- Cyclosporin + Voclosporin Contraindicada
- Ensitrelvir + Voclosporin Contraindicada
- Ketoconazole + Voclosporin Contraindicada
- Posaconazole + Voclosporin Contraindicada
- Voclosporin + Voriconazole Contraindicada
Perguntas frequentes
Can I take Itraconazole with Voclosporin?
MediHelp rates the interaction as contraindicated. Itraconazole and Voclosporin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Itraconazole markedly raises voclosporin levels, increasing risks of nephrotoxicity, hypertension, neurotoxicity and QT prolongation. Voclosporin labeling contraindicates strong CYP3A4 inhibitors.
How serious is the interaction between Itraconazole and Voclosporin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative antifungal with less CYP3A4 inhibition, monitoring renal function if unavoidable exposure occurs.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
Monografias completas, posologia e verificador de interações no app MediHelp
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