Interações medicamentosas
Ixekizumab + Quinidine
Gravidade: Leve
Ixekizumab and Quinidine: minor interaction.
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Resumo
Chronic inflammation can suppress CYP450 enzymes, and control of inflammation with IL-17A blockade may restore their activity. Quinidine has a narrow therapeutic index, so changes in its metabolism could matter. The effect is theoretical and probably small.
O que esta interação significa em palavras simples
Ixekizumab and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ixekizumab belongs to Miscellaneous; Quinidine belongs to Anti Parasitic.
Por que acontece
Cytokine normalization after IL-17A inhibition may restore CYP3A4 activity and modestly reduce quinidine exposure.
O que fazer
When ixekizumab is started or stopped, check the quinidine response, ECG and serum concentration if clinically indicated. Adjust the quinidine dose only if the response or level changes.
O que perguntar ao farmacêutico
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Outras interações de Quinidine
- Adagrasib + Quinidine Contraindicada
- Arsenic trioxide + Quinidine Contraindicada
- Artemether / lumefantrine + Quinidine Contraindicada
- Chloroquine + Quinidine Contraindicada
- Dofetilide + Quinidine Contraindicada
- Dronedarone + Quinidine Contraindicada
Outras interações de Ixekizumab
Perguntas frequentes
Can I take Ixekizumab with Quinidine?
MediHelp rates the interaction as minor. Ixekizumab and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chronic inflammation can suppress CYP450 enzymes, and control of inflammation with IL-17A blockade may restore their activity. Quinidine has a narrow therapeutic index, so changes in its metabolism could matter. The effect is theoretical and probably small.
How serious is the interaction between Ixekizumab and Quinidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: When ixekizumab is started or stopped, check the quinidine response, ECG and serum concentration if clinically indicated. Adjust the quinidine dose only if the response or level changes.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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