Interações medicamentosas
Lasmiditan + Rifaximin
Gravidade: Moderada
Lasmiditan and Rifaximin: moderate interaction.
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Resumo
Lasmiditan inhibits intestinal P-glycoprotein and may increase absorption of P-gp substrates. Rifaximin is a P-gp substrate with low normal absorption, so systemic exposure can rise, particularly with hepatic impairment. The clinical significance with usual doses is uncertain.
O que esta interação significa em palavras simples
Lasmiditan and Rifaximin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Rifaximin belongs to Anti Bacterial.
Por que acontece
Lasmiditan inhibits P-glycoprotein efflux, raising systemic exposure to rifaximin.
O que fazer
Monitor for rifaximin adverse effects, particularly in patients with severe hepatic impairment. Consider avoiding lasmiditan for a patient on long-term rifaximin with advanced liver disease.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Rifaximin
- Cholera vaccine + Rifaximin Grave
- Microbiota + Rifaximin Grave
- Amiodarone + Rifaximin Moderada
- Bcg intravesical live + Rifaximin Moderada
- Cyclosporine + Rifaximin Moderada
- Cyclosporin + Rifaximin Moderada
Outras interações de Lasmiditan
- Alprazolam + Lasmiditan Moderada
- Amiodarone + Lasmiditan Moderada
- Amisulpride + Lasmiditan Moderada
- Amobarbital + Lasmiditan Moderada
- Aripiprazole + Lasmiditan Moderada
- Asenapine + Lasmiditan Moderada
Perguntas frequentes
Can I take Lasmiditan with Rifaximin?
MediHelp rates the interaction as moderate. Lasmiditan and Rifaximin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan inhibits intestinal P-glycoprotein and may increase absorption of P-gp substrates. Rifaximin is a P-gp substrate with low normal absorption, so systemic exposure can rise, particularly with hepatic impairment. The clinical significance with usual doses is uncertain.
How serious is the interaction between Lasmiditan and Rifaximin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for rifaximin adverse effects, particularly in patients with severe hepatic impairment. Consider avoiding lasmiditan for a patient on long-term rifaximin with advanced liver disease.
What other medicines interact with Rifaximin?
MediHelp also lists interactions of Rifaximin with, for example, Cholera vaccine, Microbiota, Amiodarone. The full list is on the Rifaximin page.
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