Interações medicamentosas
Letermovir + Pitavastatin
Gravidade: Grave
Letermovir and Pitavastatin: major interaction.
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Resumo
Letermovir increases pitavastatin concentrations, and the effect is magnified when cyclosporine is also given. This raises the risk of myopathy and rhabdomyolysis.
O que esta interação significa em palavras simples
Letermovir and Pitavastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Letermovir belongs to Anti Virals; Pitavastatin belongs to Cardiovascular.
Por que acontece
Letermovir inhibits hepatic uptake transporters OATP1B1/3, raising pitavastatin exposure.
O que fazer
Avoid coadministration where possible; it is contraindicated if cyclosporine is also used. Otherwise, consider holding the statin during letermovir therapy and monitor for muscle toxicity.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Pitavastatin
- Cyclosporine + Pitavastatin Contraindicada
- Cyclosporin + Pitavastatin Contraindicada
- Erythromycin base + Pitavastatin Grave
- Erythromycin ethylsuccinate + Pitavastatin Grave
- Erythromycin lactobionate + Pitavastatin Grave
- Erythromycin stearate + Pitavastatin Grave
Outras interações de Letermovir
- Ergotamine + Letermovir Contraindicada
- Letermovir + Pimozide Contraindicada
- Apalutamide + Letermovir Grave
- Atorvastatin + Letermovir Grave
- Carbamazepine + Letermovir Grave
- Colchicine + Letermovir Grave
Perguntas frequentes
Can I take Letermovir with Pitavastatin?
MediHelp rates the interaction as major. Letermovir and Pitavastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Letermovir increases pitavastatin concentrations, and the effect is magnified when cyclosporine is also given. This raises the risk of myopathy and rhabdomyolysis.
How serious is the interaction between Letermovir and Pitavastatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration where possible; it is contraindicated if cyclosporine is also used. Otherwise, consider holding the statin during letermovir therapy and monitor for muscle toxicity.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporine, Cyclosporin, Erythromycin base. The full list is on the Pitavastatin page.
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