Interações medicamentosas
Levodopa + Phenelzine (nonselective MAOI)
Gravidade: Contraindicada
Levodopa and Phenelzine (nonselective MAOI): contraindicated interaction.
Última atualização Fontes: US FDA label
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Resumo
Levodopa with a nonselective MAOI such as phenelzine can cause hypertensive crisis because peripheral dopamine and norepinephrine accumulate. Levodopa labeling contraindicates nonselective MAOIs, which must be stopped at least two weeks beforehand. Severe headache, palpitations and dangerously high blood pressure may occur.
O que esta interação significa em palavras simples
Levodopa and Phenelzine (nonselective MAOI) are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Nonselective MAO inhibition blocks breakdown of dopamine and norepinephrine formed from levodopa, causing excessive catecholamine accumulation and a pressor response.
O que fazer
Do not combine. Stop phenelzine at least 14 days before starting levodopa.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Referências
Outras interações de Levodopa
- Isocarboxazid + Levodopa Contraindicada
- Levodopa + Phenelzine Contraindicada
- Levodopa + Procarbazine Contraindicada
- Levodopa + Tranylcypromine Contraindicada
- Amisulpride + Levodopa Grave
- Chlorpromazine + Levodopa Grave
Perguntas frequentes
Can I take Levodopa with Phenelzine (nonselective MAOI)?
MediHelp rates the interaction as contraindicated. Levodopa and Phenelzine (nonselective MAOI) are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levodopa with a nonselective MAOI such as phenelzine can cause hypertensive crisis because peripheral dopamine and norepinephrine accumulate. Levodopa labeling contraindicates nonselective MAOIs, which must be stopped at least two weeks beforehand. Severe headache, palpitations and dangerously high blood pressure may occur.
How serious is the interaction between Levodopa and Phenelzine (nonselective MAOI)?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Stop phenelzine at least 14 days before starting levodopa.
What other medicines interact with Levodopa?
MediHelp also lists interactions of Levodopa with, for example, Isocarboxazid, Phenelzine, Procarbazine. The full list is on the Levodopa page.
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