Interações medicamentosas
Isocarboxazid + Levodopa
Gravidade: Contraindicada
Isocarboxazid and Levodopa: contraindicated interaction.
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Resumo
Levodopa with a nonselective MAOI can cause hypertensive crisis. Dopamine and norepinephrine formed from levodopa are not metabolized normally.
O que esta interação significa em palavras simples
Isocarboxazid and Levodopa are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isocarboxazid belongs to Central Nervous System; Levodopa belongs to Central Nervous System.
Por que acontece
Nonselective MAO inhibition prevents breakdown of dopamine and norepinephrine formed from levodopa, producing excessive adrenergic stimulation.
O que fazer
Avoid the combination and stop the nonselective MAOI at least 2 weeks before starting levodopa. Selective MAO-B inhibitors are the acceptable alternative in Parkinson disease.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicada
- Amitriptyline + Isocarboxazid Contraindicada
- Amobarbital + Isocarboxazid Contraindicada
- Amoxapine + Isocarboxazid Contraindicada
- Apraclonidine + Isocarboxazid Contraindicada
- Atomoxetine + Isocarboxazid Contraindicada
Outras interações de Levodopa
- Levodopa + Phenelzine Contraindicada
- Levodopa + Phenelzine (nonselective MAOI) Contraindicada
- Levodopa + Procarbazine Contraindicada
- Levodopa + Tranylcypromine Contraindicada
- Amisulpride + Levodopa Grave
- Chlorpromazine + Levodopa Grave
Perguntas frequentes
Can I take Isocarboxazid with Levodopa?
MediHelp rates the interaction as contraindicated. Isocarboxazid and Levodopa are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levodopa with a nonselective MAOI can cause hypertensive crisis. Dopamine and norepinephrine formed from levodopa are not metabolized normally.
How serious is the interaction between Isocarboxazid and Levodopa?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and stop the nonselective MAOI at least 2 weeks before starting levodopa. Selective MAO-B inhibitors are the acceptable alternative in Parkinson disease.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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