Interações medicamentosas
Levodopa + Phenelzine
Gravidade: Contraindicada
Levodopa and Phenelzine: contraindicated interaction.
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Resumo
Levodopa is converted to dopamine and norepinephrine, and a nonselective MAO inhibitor prevents their breakdown. The combination can produce sudden severe hypertension and hypertensive crisis. Labeling for levodopa products contraindicates concurrent nonselective MAOIs.
O que esta interação significa em palavras simples
Levodopa and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Levodopa belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Por que acontece
Irreversible MAO inhibition by phenelzine blocks catecholamine degradation, so levodopa-derived dopamine and norepinephrine accumulate.
O que fazer
Do not combine; stop phenelzine at least 14 days before starting levodopa. Choose a non-MAOI antidepressant if one is needed in a patient on levodopa.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Phenelzine
- 5-HTP + Phenelzine Contraindicada
- Amitriptyline + Phenelzine Contraindicada
- Amoxapine + Phenelzine Contraindicada
- Atomoxetine + Phenelzine Contraindicada
- Benzphetamine + Phenelzine Contraindicada
- Brimonidine + Phenelzine Contraindicada
Outras interações de Levodopa
- Isocarboxazid + Levodopa Contraindicada
- Levodopa + Phenelzine (nonselective MAOI) Contraindicada
- Levodopa + Procarbazine Contraindicada
- Levodopa + Tranylcypromine Contraindicada
- Amisulpride + Levodopa Grave
- Chlorpromazine + Levodopa Grave
Perguntas frequentes
Can I take Levodopa with Phenelzine?
MediHelp rates the interaction as contraindicated. Levodopa and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levodopa is converted to dopamine and norepinephrine, and a nonselective MAO inhibitor prevents their breakdown. The combination can produce sudden severe hypertension and hypertensive crisis. Labeling for levodopa products contraindicates concurrent nonselective MAOIs.
How serious is the interaction between Levodopa and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; stop phenelzine at least 14 days before starting levodopa. Choose a non-MAOI antidepressant if one is needed in a patient on levodopa.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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