Interações medicamentosas
Levoketoconazole + Sirolimus
Gravidade: Contraindicada
Levoketoconazole and Sirolimus: contraindicated interaction.
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Resumo
Levoketoconazole is a strong CYP3A4 and P-gp inhibitor and can markedly raise sirolimus exposure. This may cause serious toxicity, including myelosuppression, hyperlipidemia, infection and impaired wound healing.
O que esta interação significa em palavras simples
Levoketoconazole and Sirolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Levoketoconazole belongs to Endocrine; Sirolimus belongs to Miscellaneous.
Por que acontece
Strong inhibition of CYP3A4 and P-glycoprotein reduces sirolimus metabolism and efflux.
O que fazer
Avoid the combination and use an alternative treatment. If the interaction cannot be avoided, specialist guidance and very close sirolimus level monitoring are needed.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicada
- Bcg vaccine live + Sirolimus Contraindicada
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicada
- Ketoconazole + Sirolimus Contraindicada
- Measles mumps and rubella vaccine live + Sirolimus Contraindicada
- Measles mumps and rubella vaccine + Sirolimus Contraindicada
Outras interações de Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicada
- Alprazolam + Levoketoconazole Contraindicada
- Amiodarone + Levoketoconazole Contraindicada
- Avanafil + Levoketoconazole Contraindicada
- Cisapride + Levoketoconazole Contraindicada
- Clarithromycin + Levoketoconazole Contraindicada
Perguntas frequentes
Can I take Levoketoconazole with Sirolimus?
MediHelp rates the interaction as contraindicated. Levoketoconazole and Sirolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levoketoconazole is a strong CYP3A4 and P-gp inhibitor and can markedly raise sirolimus exposure. This may cause serious toxicity, including myelosuppression, hyperlipidemia, infection and impaired wound healing.
How serious is the interaction between Levoketoconazole and Sirolimus?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative treatment. If the interaction cannot be avoided, specialist guidance and very close sirolimus level monitoring are needed.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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